Proteomic approaches in allergen analysis

Monday, 13 December 2010 11:46

Proteomics is the large-scale study of proteins, particularly their structures and functions. The methods employed in proteomic studies include multi-dimensional separation and protein identification by mass spectrometry, followed by analysis of data using bioinformatic tools. Dr Claire Mills, leader of the EuroPrevall project, and a colleague have recently reviewed the applications of proteomics in the field of food allergy.

Proteomic approaches are being used in a large number of projects including those funded under the EuroPrevall and MoniQA banners. These studies aim to improve food allergy diagnosis, therapy, and allergenic risk assessment. Further proteomic studies are seeking to identify the genetic and phenotypic variability of allergens in crops. These methods are also being used to detect and quantify allergens, either in their native form or in forms found in complex foods that result from food processing.

Reference: Sancho & Mills. 2010. Regulatory Toxicology and Pharmacology. Vol. 58(3 Suppl):S42-6.