In theory all proteins have the potential to become allergens, but a recent study from the Institute of Food Research in Norwich and the Medical University of Vienna  has found that in practice the ability of animal food proteins to act as allergens depends on their evolutionary distance from a human equivalent.

“This explains why people who are allergic to cow’s milk can often tolerate mare’s milk but not goat’s milk”, said Dr Clare Mills of the Institute of Food Research. “Proteins in horse milk are up to 66% identical to human milk proteins, while known allergens from cows and goats are all less than 53% identical to corresponding human proteins.

“Overall we found that only an animal food protein that is less than 54% identical to a human equivalent could become allergenic”.

The researchers found that the majority of animal food allergens could be classified into one of three protein families:

• Tropomyosins, found in muscle tissue, are the largest group of animal food proteins. Tropomyosins in mammals, fish and birds are at least 90% identical to at least one human tropomyosin and none have been reported to be allergenic. The allergenic tropomyosins are all from invertebrates and at most are only 55% identical to the closest human protein.
• EF-hand proteins form the second largest animal food allergen family. Those in birds and mammals are not allergenic, while those in frogs and fish are linked with allergy.
• Caseins, are all mammalian proteins from milk. The researchers analysed milk from rabbits, rats and camels as well as sheep, goats, cows and horses.

“Animal food proteins lie at the limits of the capability of the human immune system to discriminate between foreign and self proteins”, said Dr Mills. “Immune responses to some animal food allergens such as the invertebrate tropomyosins, run close to becoming a form of autoimmune response and this needs to be considered when developing allergy therapies”.

Evolutionary distance from human homologues reflects allergenicity of animal food proteins. John A. Jenkins, Heimo Breiteneder, E. N. Clare Mills. Published online by the Journal of Allergy and Clinical Immunology on October 16 2007.