Epigenetics and allergies

Thursday, 21 April 2011 10:52

A detailed literature review into epigenetics and allergies has found evidence that indicates transient environmental factors may have permanent effects on gene regulation and expression which potentially leads to the development of allergic disease.

Some of the studies reviewed show that in mouse models, a maternal diet rich in methyl donors can enhance susceptibility to allergic inflammation in the offspring. Epigenetic modification of dendritic cells, the immune cells that are in contact with the environment, may also have a role in the transfer of allergic disease from mothers to their offspring.

Further human studies are necessary to explore these mechanisms and determine relevant therapeutic options to mitigate such epigenetic effects.

Reference: North & Ellis. 2011 Annals of Allergy, Asthma & Immunology. DOI:10.1016/j.anai.2011.02.008