More evidence for sunshine hypothesis in allergy etiology

Massachusetts-based researchers have conducted a study to determine whether there are geographic differences in the rates of emergency department visits resulting from acute allergic reactions. Previous work has shown latitudinal associations with EpiPen prescription rates in the United States.

National Hospital Ambulatory Medical Care Survey data was used in the study which found that between 1993 and 2005, there were 17.3 million emergency department visits for acute allergic reactions. This number represents more than one percent of all emergency department visits.

Analysis of the data showed the rates of emergency department visit rates for acute allergic reactions are higher in north-eastern compared to southern regions of the USA. The study authors maintain these findings are consistent with the hypothesis that vitamin D may play an etiologic role in anaphylaxis, especially food-induced anaphylaxis.

Reference: Rudders et al. 2010. Annals of Allergy, Asthma and Immunology. Vol. 104(5) pp. 413-416.